Millennium Problems monogram

Millennium Problems in Biology

What are biology’s most important unsolved challenges? Inspired by the Millennium Prize Problems in mathematics, this community vote will help choose seven for biology.

Verifiable

Clear, objective criteria determine whether the problem is solved.

Frontier-defining

Solving it must require a genuine advance in biological capability or understanding.

Generative

Solving it should unlock broad new possibilities for experiments, predictions, or interventions.

Loading ballot…